When preparing a solution, which syringe should you select to ensure accuracy with a small volume?

The selection of the smallest syringe is recommended for ensuring accuracy when preparing a solution with a small volume. Smaller syringes provide a more precise scale for measuring low volumes due to their finer graduations. This precision minimizes the risk of volume error, which can significantly impact the dosage and efficacy of sterile compounded preparations.

Larger syringes, or even medium-sized syringes, generally have wider calibration markings that become less accurate at small volumes. As the volume decreases, the percentage error in the measurement can increase with these larger syringes because the differences between the calibration lines represent larger amounts of fluid.

By using the smallest syringe, the pharmacist or technician can measure and withdraw an accurate volume, which is crucial in sterile compounding where the integrity of medications is paramount. This ensures that the final product meets the required specifications and is safe for patient administration.